I'm running Omega through the Parallels program on a Mac. The F8 hot key for show filled was the first circumstance that I ran into as that key activates the spaces feature on the mac. You can change that under Expose & Spaces in the preference panel. I switched it to activate by the center button on the mac mouse or F13. Under keyboard and mouse settings in the preference panel there are quite a number of functions that look like they can be turned on or off as well.
Through the Parallels program there were some settings that caused a temporary conflict as well. Using the combination of control+shift to select individual shapes within a group of shapes in Omega was activating the right mouse button menu instead until I got that corrected.
Haven't had this set up and going for very long yet, but those are the things that I have come across so far.
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